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"The patients treated with the device had significant relief from pain and signs of increased micro-circulation, and they returned to function much faster"

Dr. Yariv Malimovka

Director, Centro Medico Vasculary Y Proctologic

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History of Ultrasound Therapy

Ultrasound technology has its roots in the 18th century research of Physiologist Lazzaro Spallanzani. His study of the bat echolocation system became the basis of all modern-day ultrasound therapy. Initially used as a means of detecting objects, ultrasound was first employed medically in the early part of the 20th century, to treat athletes and arthritis sufferers. Soon after, it also became a means of medical diagnosis.

A Comprehensive Review of Ineffectiveness of Therapeutic Ultrasound (Physical Therapy, Volume 81, Issue 7, 1 July 2001, Pages 1339–1350,) was conducted by Velama J Robertson and Kerry G Baker. Their conclusion was that:

“… Therapeutic ultrasound is one of the most widely and frequently used
electrophysical agents. Despite over 60 years of clinical use, the effectiveness of
ultrasound for treating people with pain, musculoskeletal injuries, and soft tissue
lesions remains questionable."

How are we Different?

ActiVessel is unlike any other ultrasound machine in the world. Other ultrasounds work by heating the surface of the skin and the underlying muscle, causing temporary pain relief and improving movement.
ActiVessel, by combining ultrasound with Electric Field Stimulation (EFS), is the only device in the world that bypasses the skin's impedance to reach blood vessels up to 7cm beneath the skin's surface. Its whirlpool action clears these vessels, helping to restore natural, healthy circulation.

How it Works

ActiVessel is a simple, non-invasive and fast-acting method to turn pathologically dysfunctional circulatory and lymphatic systems into healthy, functioning and effective ones. It does so by increasing blood circulation and removing inflammatory mediators from damaged tissue, causing spontaneous pain reduction.

The ActiVessel treatment is powered by a pioneering combination of Electric Field Stimulation and ultrasound. Together, they bypass the skin's impedance to boost small and large blood vessel function, increase blood supply and enable damaged tissue to recoup and regenerate. 

Unlike anti-depressant, anti-epileptic and opioid medications, which offer only short-term pain relief, ActiVessel goes straight to the heart of the problem – quickly reducing pain and promoting tissue healing, with long-lasting results and no side effects.


Key Commercial Benefit

The current paradigm in the pain treatment field today is that no lasting and significant treatment for Nerve Entrapment Syndrome exists. Doctors prescribe narcotic drugs to temporarily diminish pain, or perform surgery, which can just as easily worsen the condition as improve it.

Companies approaching these doctors with the claim of reducing patient pain for 'longer' periods, or of 'lowering' pain levels are quickly shown the door. After all, to introduce a new treatment into one's clinic requires a great deal of effort – and it's simply not worth it when the payoff is slight and short-lasting.

ActiVessel has here an enormous advantage. When clinics hear that ActiVessel has a long-term solution for Carpal Tunnel Syndrome or a Slipped Disc, they give their full, undivided attention. It is the Holy Grail in the world of pain treatment, and they will be willing to make the effort of trying it out in order to reap rewards of such magnitude.

Our Research Papers

Clinical Study: The relationship between wound healing and pain relief after the treatment with BRH-A2 system

This study was designed to test the correlation between the effect the BRH-A2 (ActiVessel) had on wound healing, and the effect it had on pain. The sample consisted of patients of various etiologies, who received treatment with the BRH-A2 system for wound healing. The main study group was 30 women with a mean age of 78.8 years. The study found that ActiVessel treatments resulted in pain decrease in alignment with wound closure and that pain decreased an average of 67 percent within 3.2 treatments.

RCSI SCHOOL OF NURSING & MIDWIFERY Report of the evaluation of the BRH-A2 Wound healing device on Chronic Diabetic Foot Ulcers

All of the wounds treated on the protocoled 8 occasions, or until closure, showed a decrease in wound size with 2 wounds completely healing. The mean wound size reduction across all wounds was 72%. This represents a good outcome in terms of wound size reduction.

Evaluation of a device combining electrostimulation and ultrasound in the treatment of non-healing chronic leg ulcers.

For many years, ultrasound and electrostimulation have been used to treat injuries such as muscle sprains, as well as to treat wounds. The BRH-A2 device combines ultrasound and electrostimulation. This study evaluated the effect of BRH-A2 on healing chronic leg ulcers and the device’s impact on pain, wellbeing and mobility.      – Ina Farrelly, Wounds International 2017, Vol 8 Issue 3

The relationship between wound healing and pain relief after the treatment with BRH-A2 (ActiVessel) system

Dr. Yelena Granovsky, PhD
Senior Lecturer, the Lab of Clinical Neurophysiology Technion Medical School;
Neurology Department, Rambam Health Care Campus Haifa, Israel
The report was prepared under the guidance of Prof. D. Yarnitsky

Conclusion: Pain relief and wound size decrease along 4 treatment sessions.


The combined use of modulated ultrasound and electric current stimulation
for diabetic foot ulcers: a case series

 T O'Connor et al.

The combined use of modulated ultrasound and electric current stimulation for diabetic foot ulcers: a case series", T. O'Connor, Z. Moore, et al, Journal of Wound Care (2017), 632-640

References & Citations

A Review of Therapeutic Ultrasound: Effectiveness Studies

Valma J. Robertson,  Kerry G Baker

Physical Therapy, Volume 81, Issue 7, 1 July 2001, Pages 1339–1350

Published: 01 July 2001

Discussion and Conclusion. There was little evidence that active therapeutic ultrasound is more effective than placebo ultrasound for treating people with pain or a range of musculoskeletal injuries or for promoting soft tissue healing.


Physiotherapy for patients with soft tissue shoulder disorders: a systematic review of randomized clinical trials.

van der Heijden GJ, van der Windt DA, de Winter AF

BMJ 1998

CONCLUSIONS: There is evidence that ultrasound therapy is ineffective in the treatment of soft tissue shoulder disorders.


Noninvasive Nonpharmacological Treatment for Chronic Pain: A Systematic Review

Andrea C. Skelly, Ph.D., M.P.H., Roger Chou, M.D., Joseph R. Dettori, Ph.D., M.P.H., M.P.T., Judith A. Turner, Ph.D., Janna L. Friedly, M.D., Sean D. Rundell, Ph.D., D.P.T., Rongwei Fu, Ph.D., Erika D. Brodt, B.S., Ngoc Wasson, M.P.H., Cassandra Winter, B.S., and Aaron J. R. Ferguson, B.A.

Comparative Effectiveness Review, No. 209 Agency for Healthcare Research and Quality (US); 2018 Jun.

CONCLUSIONS: No evidence of a difference was found between ultrasound versus sham ultrasound in short-term pain.

Mechanism of Action

Our scientists have discovered that specific application of  EFS to the ultrasound treatment area enables complete effectiveness of the ultrasonic energy for the entire duration of a treatment session. The electric field manages the bioimpedance, keeping the gateways open and allowing the full ultrasonic energy to reach the affected tissue. The complex algorithms in our patented software continually measure bioimpedance and automatically adjust the electric field, keeping the gateways clear even as the impedance changes.

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